Male doze sulfonilureje kao uspješna zamjena za inzulin u liječenju neonatalnog dijabetesa uzrokovanog aktivirajućom mutacijom Kir6.2. (CROSBI ID 561579)
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Podaci o odgovornosti
Ille, Jasenka ; Rojnic Putarek, Nataša ; Radica, Ana ; Hattersley, A ; Ellard, S ; Dumić, Miroslav
hrvatski
Male doze sulfonilureje kao uspješna zamjena za inzulin u liječenju neonatalnog dijabetesa uzrokovanog aktivirajućom mutacijom Kir6.2.
Transient (TNDM) and Permanent (PNDM) Neonatal Diabetes Mellitus are rare conditions occurring in 1:300, 000–400, 000 live births. TNDM infants develop diabetes in the first few weeks of life but go into remission in a few months, with possible relapse to a permanent diabetes state usually around adolescence or as adults. The pancreatic dysfunction in this condition may be maintained throughout life, with relapse initiated at times of metabolic stress such as puberty or pregnancy. In PNDM, insulin secretory failure occurs in the late fetal or early post-natal period and does not go into remission. Patients with TNDM are more likely to have intrauterine growth retardation and less likely to develop ketoacidosis than patients with PNDM. In TNDM, patients are younger at the diagnosis of diabetes and have lower initial insulin requirements. Considerable overlap occurs between the two groups, so that TNDM cannot be distinguished from PNDM based on clinical features. Very early onset diabetes mellitus seems to be unrelated to autoimmunity in most instances. A number of conditions are associated with PNDM, some of which have been elucidated at the molecular level. Among these, the very recently elucidated mutations in the KCNJ11 and ABCC8 genes, encoding the Kir6.2 and SUR1 subunit of the pancreatic KATP channel involved in regulation of insulin secretion, account for one third to half of the PNDM cases. Molecular analysis of chromosome 6 anomalies (found in more than 60% in TNDM), and the KCNJ11 and ABCC8 genes encoding Kir6.2 and SUR1, provides a tool to identify TNDM from PNDM in the neonatal period. This analysis also has potentially important therapeutic consequences leading to transfer some patients, those with mutations in KCNJ11 and ABCC8 genes, from insulin therapy to sulfonylureas. Recurrent diabetes is common in patients with "transient" neonatal diabetes mellitus and, consequently, prolonged follow-up is imperative. Realizing how difficult it is to take care of a child of this age with diabetes mellitus should prompt clinicians to transfer these children to specialized centers. Insulin therapy and high caloric intake are the basis of the treatment. Insulin pump may offer an interesting therapeutic tool in this age group in experienced hands.
neonatalni dijabetes; Kir6.2; glibenklamid
nije evidentirano
engleski
Low doses of glibenclamide as successful replacement for insulin therapy in a patient with neonatal diabetes due to a mutation of KCNJ11 gene encoding Kir6.2
nije evidentirano
neonatal diabetes; Kir6.2; glibenclamide
nije evidentirano
Podaci o prilogu
24-x.
2009.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
Acta clinica Croatica
Zagreb:
0353-9466
Podaci o skupu
4. Hrvatski dijabetološki kongres
poster
27.05.2009-31.05.2009
Bol, Hrvatska
Povezanost rada
Kliničke medicinske znanosti