Naslov
Myeloid/Megakaryocytic Blast Phases as a Presenting Manifestation of Chronic Myeloid Leukemia: Case Report

Autori
Milas, Ružica ; Kardum-Skelin, Ika ; Sustercic, Dunja ; Abalic, Marija ; Lebinec, M ; Predragovic, I

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Knjiga sažetaka, 4. Hrvatski kongres kliničke citologije s međunarodnim sudjelovanjem, 1. Hrvatski simpozij analitičke citologije i 2. Hrvatski simpozij citotehnologije s međunarodnim sudjelovanjem / Kardum-Skelin, Ika ; Batinić, Drago ; Anić, Veronika - Zagreb : Hrvatsko društvo za kliničku citologiju HLZ, Sekcija za analitičku citologiju, Hrvatska udruga citotehnologa, 2009

Skup
4. Hrvatski kongres kliničke citologije s međunarodnim sudjelovanjem, 1. Hrvatski simpozij analitičke citologije i 2. Hrvatski simpozij citotehnologije s međunarodnim sudjelovanjem

Mjesto i datum
Split, Hrvatska, 11.10.2009. - 14.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Chronic myeloid leukemia; blast phase with megakaryocytic and myeloid differentation

Sažetak
Chronic myeloid leukemia is a myeloproliferative disease that originate in an abnormal pluripotent bone marrow stem cell and is consistently associated with the Philadelphia chromosome and/or BCR/ABL fusion gene. The disease is bi- or triphasic: an initial indolent chronic phase is followed by one or both of the agressive transformed phase, accelerated and blast phase (crisis). The majority of patients are diagnosed in the chronic phase. The blast phase resembles acute leukemia. Blast crisis as a presentig manifestation of CML is rare. Here we report a 23-year-old man with no prior hematologic disease, who presented with fever, gluteal pain, hepatosplenomegaly, unspecific skeletal lesions. White blood count was 121, 6 x 109. Bone marrow aspiration of breastbone revealed the chronic phase of CML. Bone marrow aspiration of the pelvic bone (crista posterior) after 6 days revealed the accelerated phase of CML with 10 % atypical blasts. Bone marrow aspiration (crista posterior) after 8 days indicated blastic transformation of CML with 61% poorly differentiated blasts. Blasts expressed ANAE 75%, partly CD61 33% and MPO 21%. Using RT-PCR we detected BCR/ABL fusion gene and the abnormal fusion transcript, p210.The karyotyype was: 46, xy, t(9 ; 22) [6]/36, idem, -3, -4, del(5q), -7, del(8p), -13, -15, -16, -17, -20, -22(cp19). Here we reported the blast crisis as a presenting manifestation of CML with megakaryocytic and myeloid differentation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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