engleski

Abdominal Non-Epithelial Tumors Diagnosed by Fine Needle Aspiration Cytology

Non-epithelial tumor in abdominal cavity is less frequent finding than epithelial tumor regardless of site or primary or metastatic origin. Abdominal palpation discovers tumor mass occasionally ; therefore visualization is possible by using imaging technologies. Ultrasound (US) and computed tomography (CT) enables precise localization and tissue sampling by fine needle aspiration (FNA) for cytology analysis and additional diagnostic technologies. Material and methods: Data of 761 FNA of intraabdominal mass performed with CHIBA needle in last 10 years were analyzed. Tumor mass suitable for FNA were punctured in liver (335), pancreas (124), spleen (32) kidney (21), adrenal gland (7) and retroperitoneal and mesenterial lymph nodes (242). Smears were stained according to May-Grünwald-Giemsa and according to cytochemistry and immunocytochemistry methods. For differentiation of malignant lymphomas flow-cytometry immunofenotypisation, cytogenetic and/or molecular analysis (PCR) were additionally performed. Results: Out of total of 761 specimens malignant tumor was diagnosed in 532 (70%). Nonepithelial tumor was diagnosed in 154 (20%) - 21 sarcoma, 6 melanoma, 7 embriogenic tumors and 120 malignant lymphomas. Subtypes of sarcoma were determined based on cytomorphology and immunocytochemistry - 4 gastrointestinal stromal tumor (GIST), 3 liposarcoma, 2 rhabdomysarcoma, 2 leiomyosarcoma, 2 angiosarcoma, 1 fibrosarcoma and 7 samples were without subtype. Conclusion: US or CT guided FNA of abdominal tumor mass followed by cytoanalysis (cytochemistry and immunocytochemistry methods, flow-cytometry immunofenotypisation, cytogenetic and/or molecular analysis) is trustworthy diagnostic procedure for distinguishing non-epithelial from epithelial tumor and moreover for subtypisation of non-epithelial tumors.

fine needle aspiration cytology; abdominal non-epithelial tumor

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