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ADVERSE EVENTS IN PERIPHERAL PROGENITOR CELL COLLECTION (CROSBI ID 561526)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Jurenec, Silvana ; Minigo, Hrvoje ; Vrhovac, Radovan ; Mesarić, Jasna ADVERSE EVENTS IN PERIPHERAL PROGENITOR CELL COLLECTION // Blood Transfusion / Claudio Velati (ur.). Milano: SIMTI, 2010. str. s42-s43

Podaci o odgovornosti

Jurenec, Silvana ; Minigo, Hrvoje ; Vrhovac, Radovan ; Mesarić, Jasna

engleski

ADVERSE EVENTS IN PERIPHERAL PROGENITOR CELL COLLECTION

Background. Collection of peripheral progenitor cells (PPC) by apheresis machine is generally considered a safe procedure. Data on adverse events in PPC harvesting are scarce. According to the new Croatian legislation on tissue banking (Act on Harvesting and Transplanting Human Body Parts for Therapeutic Purpose from April 2009), it is necessary to establish monitoring and reporting serious adverse reactions and events in the field and submit a report to the Ministry of Health and Social Welfare. Aim. To present our experience on adverse events in PPC harvesting, processing, storage and transplantation. Method. In this single-center retrospective study, the PPC collections done by Cobe Spectra apheresis machine during a 34-month period (2007-2009) were reviewed. Adverse events were subdivided into harvesting procedure-associated problems, patient- donor related side effects and PPC product related side effects, including serious and non-serious adverse events. Results. A total of 140 leukapheresis were performed in 99 patients. The patient-donor related side effects occurred in 64 (46%) leukapheresis procedures, all of them manifesting as paresthesias due to citrate toxicity. Paresthesias were treated by intravenous supplementation. Problems with venous access were recorded in approximately 20% of all leukapheresis procedures. During the additional processing of PPC products to decrease their volume, the package of two transfer bags (1.5%) were damaged and the products were inappropriate for use. Conclusions. Study results showed the patient-donor related problems to occur quite frequently, however, most of them were easily overcome.

peripheral blood progenitor cell; apheresis; adverse events

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Podaci o prilogu

s42-s43.

2010.

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objavljeno

Podaci o matičnoj publikaciji

Blood Transfusion

Claudio Velati

Milano: SIMTI

1723-86172007

Podaci o skupu

International Hemovigilance Seminar

poster

17.02.2010-19.02.2010

Dubrovnik, Hrvatska

Povezanost rada

Kliničke medicinske znanosti