engleski

Erythrocyte Morphology In Malignant Urine Samples

The aim of the study was to show the origin of erythrocytes in malignant urine sample, assuming that a finding of 80% and more of dysmorphic erythrocytes indicated the bleeding to derive from upper urinary tract, and 80% and more of smooth erythrocytes indicated them to derive from lower urine tract ; in urine samples without significant origin of bleeding there were 20%-80% mixed results with both dysmorphic and isomorphic erythrocytes. Data were collected from the findings recorded in malignant urine samples received. Samples were fresh native urine sediment contrast stained with 0.1% Safranin solution and analyzed under light microscope (X40). Out of 72 patients with malignant cells detected in urine, the origin of erythrocytes was identified in 25 patients (nine female and 16 male) through 190 samples (approximately 4 samples per patient). A mixed origin of erythrocytes was identified in 70 (36.9%) samples, 55 (28.9%) samples did not have enough erythrocytes to define their origin, dysmorphic erythrocytes were found in 53 (27.9%) samples, and isomorphic erythrocytes in 12 (6.3%) samples. In conclusion, there was no specific connection between malignant cell findings in urine and origin of erythrocytes. However, the high presence of mixed erythrocyte origin in malignant samples may suggest that the existence of a malignant process and renal disease should be taken in consideration.

erythrocyte morphology; malignant urine sample

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