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Pregled bibliografske jedinice broj: 459515

Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis


Peternel, Sandra; Prpić-Massari, Larisa; Manestar-Blažić, Teo; Brajac, Ines; Kaštelan, Marija
Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis // Archives of dermatological research, 303 (2011), 6; 389-397 doi:10.1007/s00403-011-1125-0 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 459515 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis

Autori
Peternel, Sandra ; Prpić-Massari, Larisa ; Manestar-Blažić, Teo ; Brajac, Ines ; Kaštelan, Marija

Izvornik
Archives of dermatological research (0340-3696) 303 (2011), 6; 389-397

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
psoriasis; TNF-related apoptosis-inducing ligand; TRAIL Receptors; T cells; dendritic cells; macrophages

Sažetak
TNF-related apoptosis-inducing ligand (TRAIL) is recognized as an important regulator of immune responses during infections and various autoimmune-mediated pathologies. Its role in inflammatory dermatoses is largely unknown. We aimed to investigate the expression of TRAIL and its receptors DR4 and DR5 in psoriasis vulgaris. Immunohistochemistry for TRAIL, DR4 and DR5 was performed on samples of lesional (n=10) and non- lesional (n=10) skin of patients with plaque psoriasis and skin of healthy volunteers (n=10). Expression of TRAIL and its receptors was further examined by means of double immunofluorescence staining and co-localisation with CD4, CD8, CD11c, CD68, CD16 and CD56 markers. Immunohistochemical staining for TRAIL was significantly enhanced in psoriatic lesional as well as non- lesional epidermis compared to the epidermis of healthy skin. Lesional epidermis also showed increased immunoreactivity for DR5. In addition, expression of TRAIL and both of its receptors was significantly increased in the dermis of lesional skin. As evidenced by double immunofluorescence, TRAIL was readily expressed by most of the examined cells of the inflammatory infiltrate in psoriatic lesions. In contrast, expression of DR4 was found mostly among CD4+ and CD8+ cells but was only nuclear, while DR5 showed cytoplasmic staining in rare CD16+, CD56+ and CD68+ cells. According to abundant in-situ presence of TRAIL and its receptors in lesional psoriatic skin, it seems that this cytokine participates in the complex interplay between keratinocytes and cells of the dermal infiltrate and thus contributes to the inflammatory cycle in psoriasis vulgaris.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( POIROT)
062-0620239-0199 - Uloga neurogene upale i psihičkih čimbenika u patogenezi psorijaze (Brajac, Ines, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

doi www.springerlink.com

Citiraj ovu publikaciju:

Peternel, Sandra; Prpić-Massari, Larisa; Manestar-Blažić, Teo; Brajac, Ines; Kaštelan, Marija
Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis // Archives of dermatological research, 303 (2011), 6; 389-397 doi:10.1007/s00403-011-1125-0 (međunarodna recenzija, članak, znanstveni)
Peternel, S., Prpić-Massari, L., Manestar-Blažić, T., Brajac, I. & Kaštelan, M. (2011) Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis. Archives of dermatological research, 303 (6), 389-397 doi:10.1007/s00403-011-1125-0.
@article{article, year = {2011}, pages = {389-397}, DOI = {10.1007/s00403-011-1125-0}, keywords = {psoriasis, TNF-related apoptosis-inducing ligand, TRAIL Receptors, T cells, dendritic cells, macrophages}, journal = {Archives of dermatological research}, doi = {10.1007/s00403-011-1125-0}, volume = {303}, number = {6}, issn = {0340-3696}, title = {Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis}, keyword = {psoriasis, TNF-related apoptosis-inducing ligand, TRAIL Receptors, T cells, dendritic cells, macrophages} }
@article{article, year = {2011}, pages = {389-397}, DOI = {10.1007/s00403-011-1125-0}, keywords = {psoriasis, TNF-related apoptosis-inducing ligand, TRAIL Receptors, T cells, dendritic cells, macrophages}, journal = {Archives of dermatological research}, doi = {10.1007/s00403-011-1125-0}, volume = {303}, number = {6}, issn = {0340-3696}, title = {Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis}, keyword = {psoriasis, TNF-related apoptosis-inducing ligand, TRAIL Receptors, T cells, dendritic cells, macrophages} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • AGRICOLA
  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE


Citati:





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