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Pregled bibliografske jedinice broj: 459507

Linkage and genome-wide association analysis of obesity-related phenotypes : association of weight with the MGAT1 gene


Johansson, Asa; Marroni, Fabio; Hayward, Caroline; Franklin, Chris S.; Kirichenko, Alexander V.; Jonasson, Ingvar; Hicks, Andrew A.; Vitart, Veronique; Isaacs, Aaron; Axenovich, Tatiana et al.
Linkage and genome-wide association analysis of obesity-related phenotypes : association of weight with the MGAT1 gene // Obesity, 18 (2010), 4; 803-808 doi:10.1038/oby.2009.359 (međunarodna recenzija, članak, znanstveni)


Naslov
Linkage and genome-wide association analysis of obesity-related phenotypes : association of weight with the MGAT1 gene

Autori
Johansson, Asa ; Marroni, Fabio ; Hayward, Caroline ; Franklin, Chris S. ; Kirichenko, Alexander V. ; Jonasson, Ingvar ; Hicks, Andrew A. ; Vitart, Veronique ; Isaacs, Aaron ; Axenovich, Tatiana ; Campbell, Susan ; Floyd, Jamie ; Hastie, Nicholas ; Knott, Sarah ; Lauc, Gordan ; Pichler, Irene ; Rotim, Krešimir ; Wild, Sarah H. ; Zorkoltseva, Irina V. ; Wilson, James F. ; Rudan, Igor ; Campbell, Harry ; Pattaro, Christian ; Pramstaller, Peter ; Oostra, Ben A. ; Wright, Alan F. ; van Duijn, Cornelia M. ; Aulchenko, Yurii S. ; Gyllensten, Ulf ; EUROSPAN Consortium

Izvornik
Obesity (1930-7381) 18 (2010), 4; 803-808

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Genome-wide association study; obesity; MGAT1 gene; isolated populations

Sažetak
As major risk-factors for diabetes and cardiovascular diseases, the genetic contribution to obesity-related traits has been of interest for decades. Recently, a limited number of common genetic variants, which have replicated in different populations, have been identified. One approach to increase the statistical power in genetic mapping studies is to focus on populations with increased levels of linkage disequilibrium (LD) and reduced genetic diversity. We have performed joint linkage and genome-wide association analyses for weight and BMI in 3, 448 (linkage) and 3, 925 (association) partly overlapping healthy individuals from five European populations. A total of four chromosomal regions (two for weight and two for BMI) showed suggestive linkage (lod >2.69) either in one of the populations or in the joint data. At the genome-wide level (nominal P < 1.6 x 10(-7), Bonferroni-adjusted P < 0.05) one single-nucleotide polymorphism (SNP) (rs12517906) (nominal P = 7.3 x 10(-8)) was associated with weight, whereas none with BMI. The SNP associated with weight is located close to MGAT1. The monoacylglycerol acyltransferase (MGAT) enzyme family is known to be involved in dietary fat absorption. There was no overlap between the linkage regions and the associated SNPs. Our results show that genetic effects influencing weight and BMI are shared across diverse European populations, even though some of these populations have experienced recent population bottlenecks and/or been affected by genetic drift. The analysis enabled us to identify a new candidate gene, MGAT1, associated with weight in women.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom (Gordan Lauc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Split,
GENOS d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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