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Pregled bibliografske jedinice broj: 459377

Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages


Matulić, Maja; Paradžik, Mladen; Jelić Puškarić, Biljana; Stipić, Jagoda; Antica, Mariastefania
Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages // Collegium antropologicum, 34 (2010), 1; 59-62 (međunarodna recenzija, članak, znanstveni)


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Naslov
Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages

Autori
Matulić, Maja ; Paradžik, Mladen ; Jelić Puškarić, Biljana ; Stipić, Jagoda ; Antica, Mariastefania

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 1; 59-62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ikaros; Aiolos; Helios; transcription factors; gene expression; leukemia

Sažetak
Transcription factors from the Ikaros family are involved in lymphocyte differentiation and have a critical role at specific check points of the haemopoietic pathway. However, how developmentally regulated changes are reflected in gene expression programs of lymphocyte differentiation is not well understood. It has been suggested that disregulation of transcription factors from the Ikaros family is associated with the development of different human leukemias. In this work we analyzed the state of Ikaros family members in different leukemic cells with the aim to explore the transcriptional control of human hematopoietic lineages and shed some new light on our understanding of transcription factor significance in human leukemias. By means of RT-PCR and specific primers we investigated the expression of Ikaros, Aiolos and Helios transcription factors and their splicing variants in seven leukemia cell lines derived from different types of leukemia (ALL, CML, AML) and lymphoma (histiocytic lymphoma, Burkitt lymphoma and anaplastic large cell lymphoma). In all of the cell lines examined Ikaros was present in dominant Ik1 to Ik4 isoforms and small Ik6 isoform was absent. Aiolos was expressed in the majority of the cell lines, of both, B and T origin, in the form of the full length Aio1. Helios was also present only in two long isoforms Hel1 and Hel2, and was absent in one third of the lines. Similar distribution of positive and negative expression of Aiolos and Helios found in various types of leukemias could implicate common pathways of their regulation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Mariastefania Antica, )
098-0982913-2858 - Regulacija dinamike citoskeleta u kretanju i diobi stanica (Igor Weber, )
119-0000000-3172 - Poli(ADPribozilacija, starenje i plazminogenska aktivacija u tumorskim stanicama (Maja Matulić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Matulić, Maja; Paradžik, Mladen; Jelić Puškarić, Biljana; Stipić, Jagoda; Antica, Mariastefania
Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages // Collegium antropologicum, 34 (2010), 1; 59-62 (međunarodna recenzija, članak, znanstveni)
Matulić, M., Paradžik, M., Jelić Puškarić, B., Stipić, J. & Antica, M. (2010) Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages. Collegium antropologicum, 34 (1), 59-62.
@article{article, year = {2010}, pages = {59-62}, keywords = {Ikaros, Aiolos, Helios, transcription factors, gene expression, leukemia}, journal = {Collegium antropologicum}, volume = {34}, number = {1}, issn = {0350-6134}, title = {Analysis of Ikaros Family Splicing Variants in Human Hematopoietic Lineages}, keyword = {Ikaros, Aiolos, Helios, transcription factors, gene expression, leukemia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE