Expression of cytokine genes in peripheral blood mononuclear cells of patients undergoing postmastectomy radiotherapy (CROSBI ID 87838)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Juretić, Antonio ; Šamija, Mirko ; Spagnoli, C, Giulio ; Krajina, Zdenko ; Živković, Mirko ; Herceg, Tonko ; Šobat, Hrvoje ; Bistrović, Matija ; Eljuga, Damir ; Turić, Marko ; Zuber, Marcus ; Heberer, Michael
engleski
Expression of cytokine genes in peripheral blood mononuclear cells of patients undergoing postmastectomy radiotherapy
Methods. Freshly isolated PBMC collected from fifteen patients before, during, and at the end of irradiation treatment were studied by a reverse transcription-polymerase chain reaction (RT-PCR). Results. IL-1a, IL-2, IL-5, and INFg gene transcripts were rarely or never detectable, whereas IL-10 expression was often observed in the pre-treatment samples. Conclusion. These data, obtained by taking advantage of a sensitive technique closely reflecting in vivo events, suggest that systemic monocyte activation could take place in therapeutically irradiated patients.
RT-PCR ; cytokine genes
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