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Pregled bibliografske jedinice broj: 458872

Myod And Myogenin Expression In Skeletal Muscles During Regeneration


Šoić Vranić, Tamara; Nikolić, Marina; Bajek, Snježana; Starčević Klasan, Gordana; Jerković, Romana; Arbanas, Juraj; Malnar, Daniela
Myod And Myogenin Expression In Skeletal Muscles During Regeneration // Journal of Muscle Research and Cell Motility / – / Bastide B, Stevens L (ur.).
Lille: Springer Netherlands, 2009. str. 307-338 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Myod And Myogenin Expression In Skeletal Muscles During Regeneration

Autori
Šoić Vranić, Tamara ; Nikolić, Marina ; Bajek, Snježana ; Starčević Klasan, Gordana ; Jerković, Romana ; Arbanas, Juraj ; Malnar, Daniela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Muscle Research and Cell Motility / – / Bastide B, Stevens L - Lille : Springer Netherlands, 2009, 307-338

Skup
38 th European Muscle Conference

Mjesto i datum
Lille, France, September 12-16, 2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Skeletal muscle; regeneration

Sažetak
AIM The family of muscle specific basic helix-loop-helix (bHLH) regulatory factors consists of MyoD, Myf-5, myogenin and MRF4. These factors contribute to the transcriptional activation of muscle genes during commitment and differentiation. A distinct role for the bHLH myogenic factors initially was suggested by their different temporal expression patterns in the somites and limbs during embryonic development. The aim of this study was to determinate time course expression of MyoD and myogenin during regeneration in muscles of different developmental origin and different rat strains. MATERIALS AND METHODS All experiments were performed on male Wistar rats and male Sprague-Dawley rats. Histochemical, immunohistochemical and Western blot analysis were performed on m. tibialis anterior and m. masseter. Regeneration process of skeletal muscles was induced by injection of bupivacain. RESULTS AND CONCLUSIONS We have demonstrated that muscle regeneration caused a transient upregulation of MyoD and myogenin, but after reestablishment of normal muscle architecture there was no expression of MyoD and myogenin. Time course expression of MyoD and myogenin during regeneration in muscles of different developmental origin was similar. The main conclusion of our investigation is that the role of MyoD and myogenin is potentially as important in managing an adaptive and regenerative response of muscle fibers.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-1352 - Utjecaj hiperbarične oksigenacije na regeneraciju skeletnog mišića i živca (Snježana Bajek, )
062-0000000-3093 - Učinkovitost polariziranog svjetla i čimbenika rasta na denervirani mišić (Daniela Malnar, )
062-0620529-0517 - Regeneracija mozga, perifernog živca i skeletnog mišića u šećernoj bolesti (Romana Jerković, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE