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Adiponectin and leptin serum concentrations in dyslipidemic subjects with small dense LDL particles

Adiponectin and leptin are proteins secreted by the adipose tissue. They play a significant role in the regulation of lipid and carbohydrate metabolism. There is growing evidence that adiponectin has a protective effect against atherosclerosis and has recently been found to be decreased in coronary artery disease. Plasma leptin has been suggested to be involved in the proatherogenic process by increasing oxidative stress. Small dense LDL are potent atherogenic lipoprotein subclass and has been accepted as an emerging cardiovascular risk. We investigated the relationship between serum levels of adiponectin and leptin and the occurence of small dense LDL particles (pattern B) to evaluate the possible influence of these two adipokines on LDL particle size distribution. We determined serum leptin and adiponectin concentrations in group of 42 dyslipidemic subject and in a group of 18 healthy blood donors with normal lipid profile and normal distribution of LDL particle size (pattern A). Serum leptin and adiponectin concentrations were determined by comercially available ELISA test (Mediagnost, Germany). LDL particle size determination was performed by non-denaturing horizontal gradient polyacrylamide gel electrophoresis developed in our laboratory. Our preliminary results suggest that an atherogenic lipoprotein phenotype including hypertriglyceridemia, low HDL-cholesterol and also a small LDL particle size are associated with a lower serum adiponectin concentrations and a higher serum leptin concentrations.

Adiponectin; leptin; LDL-particles

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