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Pregled bibliografske jedinice broj: 457193

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans


Knežević, Ana; Gornik, Olga; Polašek, Ozren; Pučić, Maja; Redžić, Irma; Novokmet, Mislav; Rudd, Pauline M; Wright, Alan F.; Campbell, Harry; Rudan, Igor; Lauc, Gordan
Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans // Glycobiology, 20 (2010), 8; 959-969 (međunarodna recenzija, članak, znanstveni)


Naslov
Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans

Autori
Knežević, Ana ; Gornik, Olga ; Polašek, Ozren ; Pučić, Maja ; Redžić, Irma ; Novokmet, Mislav ; Rudd, Pauline M ; Wright, Alan F. ; Campbell, Harry ; Rudan, Igor ; Lauc, Gordan

Izvornik
Glycobiology (0959-6658) 20 (2010), 8; 959-969

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-glycans; human plasma glycome; ageing; body fat; smoking

Sažetak
Protein glycosylation affects nearly all molecular interactions at the cell surface and in the intercellular space. Many of the physiological variations which are part of homeostatic mechanisms influence glycosylation. However, a comprehensive overview of changes in glycosylation caused by aging and common lifestyle parameters is still lacking. After analyzing N-glycans in plasma of 1, 914 individuals from Croatian islands of Vis and Korčula we performed a comprehensive analysis of the dependence of different glycosylation features (position of fucose, level of galactosylation, sialylation and branching) on aging, smoking, body fat and plasma lipid status. A number of statistically significant associations were observed. Glycosylation changes with aging were especially evident in females, mostly in association with the transition from pre-menopausal to post-menopausal age. Levels of core fucosylated, nongalactosylated, digalactosylated and disialylated biantennary glycans were shown to be mainly age dependent, but the level of branching and higher levels of galactosylation were found to correlate with lipid status. For the majority of glycans which we analyzed all examined parameters explained up to 5% of the variance. The only notable exception were nongalactosylated glycans where 20% of the variance was explained, mostly by age and blood pressure. In general, only a small fraction of the variability in glycan levels observed in a population was explained by age and other measured parameters, indicating that even in the absence of a genetic template, glycan levels are mostly determined by genetic background and/or specific pathophysiological processes.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom (Gordan Lauc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split,
GENOS d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE