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Pregled bibliografske jedinice broj: 456074

Autologous Bone Grafting on Steroids : Preliminary Clinical Results. A Novel Treatment for Nonunions and Segmental Bone Defects


Miller, M.A.; Ivković, Alan; Porter, R.M.; Estok, D.M.; Smith, R.M.; Evans, C.H.; Vrahas, M.S.
Autologous Bone Grafting on Steroids : Preliminary Clinical Results. A Novel Treatment for Nonunions and Segmental Bone Defects // International orthopaedics, 35 (2011), 4; 599-605 doi:10.1007/s00264-010-1013-9 (međunarodna recenzija, članak, znanstveni)


Naslov
Autologous Bone Grafting on Steroids : Preliminary Clinical Results. A Novel Treatment for Nonunions and Segmental Bone Defects

Autori
Miller, M.A. ; Ivković, Alan ; Porter, R.M. ; Estok, D.M. ; Smith, R.M. ; Evans, C.H. ; Vrahas, M.S.

Izvornik
International orthopaedics (0341-2695) 35 (2011), 4; 599-605

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Autologous Bone Grafting; steroids; bone defects

Sažetak
Clinical management of delayed healing or nonunion of long bone fractures and segmental bone defects poses a substantial orthopaedic challenge. Surgical advances and bone tissue engineering are providing new avenues to stimulate bone growth in cases of bone loss and nonunion. The reamer-irrigator-aspirator (RIA) device allows surgeons to aspirate the medullary contents of long bones and use the progenitor-rich “flow-through” fraction in autologous bone grafting. Dexamethasone (DEX) is a synthetic steroid that has been shown to induce osteoblastic differentiation. A series of 13 patients treated with RIA bone grafting enhanced with DEX for nonunion or segmental defect was examined retrospectively to assess the quality of bony union and clinical outcomes. Despite the initial poor prognoses, promising results were achieved using this technique ; and given the complexity of these cases the observed success is of great value and warrants controlled study into both standardisation of the procedure and concentration of the grafting material.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-0000000-3652 - Genska terapija mineraliziranih tkiva (Marko Pećina, )

Ustanove
Medicinski fakultet, Zagreb,
Sveučilište u Rijeci

Autor s matičnim brojem:
Alan Ivković, (315285)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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