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Pregled bibliografske jedinice broj: 455349

Role of interleukin-8 (IL-8), macrophage inflammatory proteins-1 beta (MIP-1B)and monocyte chemoattractant protein-1 (MCP-1) in pathogenesis of Mycoplasma pneumoniae community-acquired pneumonia


Puljiz, Ivan; Markotić, Alemka; Krajinović Cvetko, Lidija; Gužvinec, Marija; Kuzman, Ilija; Polašek, Ozren
Role of interleukin-8 (IL-8), macrophage inflammatory proteins-1 beta (MIP-1B)and monocyte chemoattractant protein-1 (MCP-1) in pathogenesis of Mycoplasma pneumoniae community-acquired pneumonia // Chest (2011) (znanstveni, poslan)


Naslov
Role of interleukin-8 (IL-8), macrophage inflammatory proteins-1 beta (MIP-1B)and monocyte chemoattractant protein-1 (MCP-1) in pathogenesis of Mycoplasma pneumoniae community-acquired pneumonia

Autori
Puljiz, Ivan ; Markotić, Alemka ; Krajinović Cvetko, Lidija ; Gužvinec, Marija ; Kuzman, Ilija ; Polašek, Ozren

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Chest (2011)

Status rada
Poslan

Ključne riječi
Interleukin-8; macrophage inflammatory proteins-1; monocyte chemoattractant protein-1; Mycoplasma pneumoniae
(Iinterleukin-8; macrophage inflammatory proteins-1; monocyte chemoattractant protein-1; Mycoplasma pneumoniae)

Sažetak
The objective of this study was to assess the concentration of interleukin-8 (IL-8), macrophage inflammatory proteins-1 (MIP-1), and monocyte chemoattractant protein-1 (MCP-1) in peripheral circulation and their mRNA expression in peripheral blood mononuclear leukocytes (MNLs) in patients with community acquired pneumonia (CAP) caused by Mycoplasma pneumoniae. We prospectively analyzed MMPs in 40 hospitalized patients with M. pneumoniae CAP on admission, and in the convalescent phase. Sera from 20 health male age between 15-50 years were used as controls. The gene expression in MNLs of IL-8 were greater in acute stage of M. pneumoniae CAP than in control group. Furthermore in convalescent gene expression was increased. The difference was statistical significant between patients in acute stage and convalescent regarding control group (p=0, 013 ; p=0, 001, respectively). Serum IL-8 concentration were higher in acute stage of pneumonia than in control group with statistical differences (p=0, 033). The gene expression of MCP-1 were on basal level in all examined group. However, serum concentration of MCP-1 was higher in control group than patients in acute and convalescent stage M. pneumoniae CAP. The difference was statistical significant between control group and patients in acute stage (p=0, 012). The gene expression of MIP1ß in MNLs were greater in acute stage of M. pneumoniae CAP than control group and convalescent stage with statistical difference (p>0, 001 ; p=0, 001, respectively). Serum MIP-1ß concentration were similiar patients in acute phase, reconvalescent and control group. Spearman`s correlation test in our patients showed correlation between gene expression of MIP1ß and neutrophil count in peripheral circulation (r=0, 40, p=0, 025). In conclusion, there was a associated between pathogenesis of CAP caused by M. pneumoniae and the develepment of IL-8 and MIP-ß mRNA expression in peripheral MNLs. Furthernmore, IL-8 plasma concentration suggest involved these chemokine in pathogenesis of disease. Plasma level of MCP-1 perhaps indicate escape in peripheral circulation and accumulation in pulmonary compartment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-0000000-3491 - ISTRAŽIVANJE ETIOLOGIJE I PATOGENEZE PNEUMONIJA (Ilija Kuzman, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE