Napredna pretraga

Pregled bibliografske jedinice broj: 454260

Passive immunization prevents MCMV-induced pathology in the CNS of newborn mice


Cekinović, Đurđica; Golemac, Mio; Pernjak Pugel, Ester; Tomac, Jelena; Čičin-Šain, Luka; Slavuljica, Irena; Bradford, Russel; Winkler, Thomas H.; Misch, Sonja; Mach, Michael et al.
Passive immunization prevents MCMV-induced pathology in the CNS of newborn mice // 2008 Annual Meeting of the Croatian Immunological Society ; Book of abstracts / Rabatić Sabina (ur.).
Zagreb, 2008. (poster, domaća recenzija, sažetak, znanstveni)


Naslov
Passive immunization prevents MCMV-induced pathology in the CNS of newborn mice

Autori
Cekinović, Đurđica ; Golemac, Mio ; Pernjak Pugel, Ester ; Tomac, Jelena ; Čičin-Šain, Luka ; Slavuljica, Irena ; Bradford, Russel ; Winkler, Thomas H. ; Misch, Sonja ; Mach, Michael ; Britt, William J. ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2008 Annual Meeting of the Croatian Immunological Society ; Book of abstracts / Rabatić Sabina - Zagreb, 2008

Skup
2008 Annual Meeting of the Croatian Immunological Society

Mjesto i datum
Šibenik, Hrvatska, 09-12.10.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Passive immunization; MCMV; CNS pathology
(Passive immunization; MCMV; CNS pathology;)

Sažetak
Human cytomegalovirus (HCMV) infection of the central nervous system (CNS) is the most frequent cause of congenital abnormalities that include learning disabilities, microcephaly and hearing loss. The pathogenesis of the CNS infection is still insufficiently defined, and may arise upon direct damage of CMV-infected neurons or indirectly, due to inflammatory response to infection. We used a recently established model of murine CMV (MCMV) infection in newborn mice (Koontz T. et al. J. Exp. Med. 2008) to analyze the contribution of humoral immunity to virus clearance from the brain. In brains of MCMV-infected newborn mice treated with immune serum virus titer was reduced below detection limit as compared to brains of mice receiving control (non-immune) serum where significant amounts of virus were recovered. Histopathological analyses revealed significantly less CNS inflammation in immune serum treated mice. The same reduction of virus titer in the brain was finding after treatment with MCMV specific monoclonal antibodies. Recipients of control serum or irrelevant antibodies had more viral foci, marked mononuclear cell infiltrates and prominent glial nodules in their brains. Antiviral antibodies were also effective in preventing virus associated developmental abnormalities in MCMV-infected newborn brain in terms of improved neuronal migration and increased cerebellar area as compared to control mice. In conclusion, our data indicate that virus specific antibodies have a protective role in the development of CNS pathology in MCMV infected newborn mice, suggesting that antiviral antibodies are an important component of immunological responses during CMV infection of developing CNS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1265 - Citomegalovirusna infekcija ovarija (Jelena Tomac, )
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Ester Pernjak-Pugel, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Cekinović, Đurđica; Golemac, Mio; Pernjak Pugel, Ester; Tomac, Jelena; Čičin-Šain, Luka; Slavuljica, Irena; Bradford, Russel; Winkler, Thomas H.; Misch, Sonja; Mach, Michael et al.
Passive immunization prevents MCMV-induced pathology in the CNS of newborn mice // 2008 Annual Meeting of the Croatian Immunological Society ; Book of abstracts / Rabatić Sabina (ur.).
Zagreb, 2008. (poster, domaća recenzija, sažetak, znanstveni)
Cekinović, Đ., Golemac, M., Pernjak Pugel, E., Tomac, J., Čičin-Šain, L., Slavuljica, I., Bradford, R., Winkler, T., Misch, S. & Mach, M. (2008) Passive immunization prevents MCMV-induced pathology in the CNS of newborn mice. U: Rabatić Sabina (ur.)2008 Annual Meeting of the Croatian Immunological Society ; Book of abstracts.
@article{article, year = {2008}, keywords = {passive immunization, MCMV, CNS pathology, }, title = {Passive immunization prevents MCMV-induced pathology in the CNS of newborn mice}, keyword = {passive immunization, MCMV, CNS pathology, }, publisherplace = {\v{S}ibenik, Hrvatska} }