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Pregled bibliografske jedinice broj: 454160

Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine


Herak-Coen, Desiree; Antolić Radić, Margareta; Krleža Laniček, Jasna; Pavić, Marina; Dodig, Slavica; Đuranović, Vlasta; Brkić Basanec, Anica; Zadro, Renata
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine // Pediatrics, 123 (2009), 4; 653-660 doi:10.1542/peds.2007-3737 (međunarodna recenzija, članak, znanstveni)


Naslov
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine

Autori
Herak-Coen, Desiree ; Antolić Radić, Margareta ; Krleža Laniček, Jasna ; Pavić, Marina ; Dodig, Slavica ; Đuranović, Vlasta ; Brkić Basanec, Anica ; Zadro, Renata

Izvornik
Pediatrics (0031-4005) 123 (2009), 4; 653-660

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
inherited prothrombotic risk factors ; children ; stroke ; transient ischemic attack ; migraine

Sažetak
OBJECTIVE: The aim of this study was to investigate the prevalence and possible association of inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. METHODS: We performed genotypic analysis for factor V G1691A, factor II G20210A, methylenetetrahydrofolate reductase C677T, and 4 common platelet glycoprotein polymorphisms (human platelet alloantigen-1, -2, -3, and -5) in 150 children <18 years of age with established diagnoses of stroke, transient ischemic attack, or migraine. Children were classified into 5 groups, namely, childhood arterial ischemic stroke (N = 33), perinatal arterial ischemic stroke (N = 26), hemorrhagic stroke (N = 20), transient ischemic attack (N = 36), and migraine (N = 35). The control group consisted of 112 children < or =18 years of age from the same geographical region who had no history of neurologic or thromboembolic diseases. RESULTS: Heterozygosity for factor V G1691A was associated with approximately sevenfold increased risk for arterial ischemic stroke, perinatal arterial ischemic stroke, and transient ischemic attack. Increased risk for transient ischemic attack was found in carriers of the human platelet alloantigen-2b allele, human platelet alloantigen-5a/b genotype, and combined human platelet alloantigen-2b and human platelet alloantigen-5b genotype. The presence of the human platelet alloantigen-2b allele was associated with a 2.23-fold increased risk for migraine, whereas carriers of the human platelet alloantigen-3b allele had a lower risk for arterial ischemic stroke than did carriers of the human platelet alloantigen-3a allele. CONCLUSIONS: Factor V G1691A has an important role in susceptibility to arterial ischemic stroke, both in the perinatal/neonatal period and in childhood, as well as transient ischemic attacks. A minor impact of human platelet alloantigen polymorphisms suggests that platelet glycoprotein polymorphisms may increase the risk of transient ischemic attacks and migraine, but this should be confirmed in larger studies.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0214212
072-1081870-0025 - Neurorazvojni ishod djece s intrauterinim zastojem rasta i/ili hipoksijom (Vlatka Mejaški-Bošnjak, )
277-2770966-0965 - Kondenzat izdaha kao izvor biomarkera plućnih bolesti u djece (Slavica Dodig, )

Ustanove
Klinika za dječje bolesti Medicinskog fakulteta,
Zdravstveno veleučilište, Zagreb

Profili:

Avatar Url Slavica Dodig (autor)

Avatar Url Vlasta Đuranović (autor)

Avatar Url Renata Zadro (autor)

Avatar Url Marina Pavić (autor)

Citiraj ovu publikaciju

Herak-Coen, Desiree; Antolić Radić, Margareta; Krleža Laniček, Jasna; Pavić, Marina; Dodig, Slavica; Đuranović, Vlasta; Brkić Basanec, Anica; Zadro, Renata
Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine // Pediatrics, 123 (2009), 4; 653-660 doi:10.1542/peds.2007-3737 (međunarodna recenzija, članak, znanstveni)
Herak-Coen, D., Antolić Radić, M., Krleža Laniček, J., Pavić, M., Dodig, S., Đuranović, V., Brkić Basanec, A. & Zadro, R. (2009) Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine. Pediatrics, 123 (4), 653-660 doi:10.1542/peds.2007-3737.
@article{article, year = {2009}, pages = {653-660}, DOI = {10.1542/peds.2007-3737}, keywords = {inherited prothrombotic risk factors, children, stroke, transient ischemic attack, migraine}, journal = {Pediatrics}, doi = {10.1542/peds.2007-3737}, volume = {123}, number = {4}, issn = {0031-4005}, title = {Inherited prothrombotic risk factors in children with stroke, transient ischemic attack, or migraine}, keyword = {inherited prothrombotic risk factors, children, stroke, transient ischemic attack, migraine} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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