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Funding source and clinical trial outcome.

We disagreed that large, prospective, multicenter collaborative trials that involve hundreds of patients and critically evaluate treatments are a guarantee of valid results and instead found that such trials’ results certainly may leave room for questions. We did so in light of significant shortcomings that were found within several similarly organized studies published in leading orthopedic journals.

Funding source; clinical trial outcome; recombinant human bone morphogenetic protein type 2; spine procedure

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