engleski

Re: Toth JM, Boden SD, Burkus JK, et al. Short-term osteoclastic activity induced by locally high concentrations of recombinant human bone morphogenetic protein-2 in a cancellous bone environment. Spine 2009 ; 34:539-50.

The local high rhBMP-2 concentration was suspected by Toth et al. as the reason for high incidence of the resorptions in some studies. However, there are reports, where even higher concentrations of rhBMP-2 were used, and no resorption was reported.

recombinant human bone morphogenetic protein-2; lumbar interbody fusion; adverse effect; bone resorption

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