engleski

CD38 antigen on bronchoalveolar (BAL) T lymphocytes correlates with activation status in interstitial pulmonary diseases (ILD).

As shown in or previous OGAI reports, CD38 antigen plays a relevant risk in sarcoidosis. In this study we were interested in evaluating the role of CD38 in the pathogenesis of other ILD. BAL was obtained from patients with sarcoidosis (active and inactive, AS and IS, respectively) n=31, fibrosis (F) N=8 and controls n=14. The CD38 was highly elevated in AS (40±20%) in comparison to IS, F and C samples (≈20%). The subset analysis revealed that CD4+CD38+ cells were highly elevated in AS (29±17) as compared to IS (5±3) and F (6±4), whereas CD8+CD38+ were generally low. Eight patients underwent 2-6 repeated lavages and this follow up study indicated that CD4+CD38+ are elevated on the onset of the disease, decreased after therapy and increased again in relapse of the disease. Steroid therapy slowly increase CD8+CD38+ up to 10%. As local CD4+CD38+ expression correlate with the onset of alveolitis, Erythrema nodosum and disease progression, our results indicate that this subpopulation may play a relevant role in ILD and could serve as an indicator of disease severity

CD38; BAL; interstitial lung diseases

nije evidentirano