Napredna pretraga

Pregled bibliografske jedinice broj: 452556

Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs

Sabolić, Ivan; Breljak, Davorka; Škarica, Mario; Herak-Kramberger, Carol M.
Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs // BioMetals, 23 (2010), 5; 897-926 doi:10.1007/s10534-010-9351-z (međunarodna recenzija, pregledni rad, znanstveni)

Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs

Sabolić, Ivan ; Breljak, Davorka ; Škarica, Mario ; Herak-Kramberger, Carol M.

BioMetals (0966-0844) 23 (2010), 5; 897-926

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Antioxidants; heavy metals; hepatotoxicity; nephrotoxicity; oxidative stress; reactive oxygen species; urine metallothionein

Metallothioneins are cysteine-rich, small metal-binding proteins present in various mammalian tissues. Of the four common metallothioneins, MT-1 and MT-2 (MTs) are expressed in most tissues, MT-3 is predominantly present in brain, whereas MT-4 is restricted to the squamous epithelia. The expression of MT-1 and MT-2 in some organs exhibits sex, age, and strain differences, and inducibility with a variety of stimuli. In adult mammals, MTs have been localized largely in the cell cytoplasm, but also in lysosomes, mitochondria and nuclei. The major physiological functions of MTs include homeostasis of essential metals Zn and Cu, protection against cytotoxicity of Cd and other toxic metals, and scavenging free radicals generated in oxidative stress. The role of MTs in Cd-induced acute and chronic toxicity, particularly in liver and kidneys, is reviewed in more details. In acute toxicity, liver is the primary target, whereas in chronic toxicity, kidneys are major targets of Cd. The intracellular MTs bind Cd ions and form CdMT. In chronic intoxication, Cd stimulates de novo synthesis of MTs ; it is assumed that toxicity in the cells starts when loading with Cd ions exceeds the buffering capacity of intracellular MTs. CdMT, released from the Cd-injured organs, or when applied parenterally for experimental purposes, reaches the kidneys via circulation, where it is filtered, endocytosed in the proximal tubule cells, and degraded in lysosomes. Liberated Cd can immediately affect the cell structures and functions. The resulting proteinuria and CdMT in the urine can be used as biomarkers of tubular injury.

Izvorni jezik

Znanstvena područja
Temeljne medicinske znanosti


Projekt / tema
022-0222148-2146 - Bubrežni prijenosnici u sisavaca; spolne razlike i učinci toksičnih metala (Ivan Sabolić, )

Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

Uključenost u ostale bibliografske baze podataka:

  • BIOSIS Previews (Biological Abstracts)
  • CAB Abstracts
  • EMBASE (Excerpta Medica)
  • Toxicology Abstracts