engleski

Molecular alterations of E-cadherin and beta-catenin in brain metastases

In the present study 47 brain metastases were analyzed regarding changes of E-cadherin (CDH1) and beta-catenin (CTNNB1) genes and proteins. Our idea was that the analysis of distant metastases could elucidate the consequence of tumor progression in regard of its mutational complexity.

E-cadherin (CDH1) ; beta-catenin (CTNNB1) ; brain metastasis ; loss of heterozygosity ; heteroduplex ; image analysis ; immunostaining

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