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Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers


Kašuba, Vilena; Rozgaj, Ružica; Milić, Mirta; Želježić, Davor; Kopjar, Nevenka; Pizent, Alica; Kljaković-Gašpić, Zorana
Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers // JAT. Journal of applied toxicology, 30 (2010), 4; 321-328 doi:10.1002/jat.1497 (međunarodna recenzija, članak, znanstveni)


Naslov
Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers

Autori
Kašuba, Vilena ; Rozgaj, Ružica ; Milić, Mirta ; Želježić, Davor ; Kopjar, Nevenka ; Pizent, Alica ; Kljaković-Gašpić, Zorana

Izvornik
JAT. Journal of applied toxicology (0260-437X) 30 (2010), 4; 321-328

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Battery workers; micronuclei; blood lead and cadmium level; serum folate; serum Vitamin B12; delta aminolevulinic acid dehydratase; erythrocyte protoporphyrin

Sažetak
The influence of exposure to lead on the frequency of micronuclei (MN), nuclear buds and nucleoplasmatic bridges was investigated in peripheral blood lymphocytes in 15 male battery-manufacturing workers and 15 controls matched for age and smoking habits. In addition to MN test, blood lead (B-Pb) and cadmium (B-Cd), delta aminolevulinic acid dehydratase (ALAD) activity, erythrocyte protoporphyrin (EP), serum vitamin B12 (S-Vit B12) and folate (S-folate) were determined in all subjects. Lead-exposed subjects had significantly higher MN frequency and B-Pb concentrations than controls. In control smokers we found a significant negative correlation between B-Pb concentration and frequency of nucleoplasmatic bridges, and nuclear division index. In control non-smokers a significant positive correlation was observed only between age and nuclear buds frequency, and between S-folate and B-Pb level. In lead exposed smokers, significant positive correlations between MN frequency and S-Vit B12, S-folate, and nuclear buds frequency were found. A positive correlation in exposed smokers was also found between nuclear buds frequency and S-Vit B12 concentration. A negative correlation was found between ALAD and EP, and B-Pb in exposed smokers. Exposed non-smokers showed significant negative correlation between MN frequency and B-Cd, and ALAD and EP. The results indicate a genotoxicity of lead, pointing to a micronucleus assay as a relevant test for assessing genotoxic effects resulting from occupational exposure. The other indicators did not necessarily follow the results of MN test. Influence of smoking should be further investigated. Copyright Ó John Wiley & Sons, Ltd.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
022-0222411-2408 - Učinci toksičnih i esencijalnih metala na reprodukcijsko zdravlje muškaraca (Alica Pizent, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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