Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Traumatic brain injury in mice and pentadecapeptide BPC 157 effect (CROSBI ID 160393)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Tudor, Mario ; Jandrić, Ivan ; Marović, Anton ; Gjurašin, Miroslav ; Perović, Darko ; Radić, Božo ; Boban Blagaić, Alenka ; Kolenc, Danijela ; Brčić, Luka ; Žarković, Kamelija et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect // Regulatory peptides, 160 (2010), 1-3; 26-32. doi: 10.1016/j.regpep.2009.11.012

Podaci o odgovornosti

Tudor, Mario ; Jandrić, Ivan ; Marović, Anton ; Gjurašin, Miroslav ; Perović, Darko ; Radić, Božo ; Boban Blagaić, Alenka ; Kolenc, Danijela ; Brčić, Luka ; Žarković, Kamelija ; Seiwerth, Sven ; Sikirić, Predrag

engleski

Traumatic brain injury in mice and pentadecapeptide BPC 157 effect

Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported, improved muscle crush injury. After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0 µg, 10.0 ng/kg i.p.) demonstrated a marked attenuation of damage with an improved early outcome and a minimal postponed mortality throughout a 24 h post-injury period. Ultimately, the traumatic lesions (subarachnoidal and intraventricular haemorrhage, brain laceration, haemorrhagic laceration) were less intense and consecutive brain edema had considerably improved. Given prophylactically (30 min before TBI) the improved conscious/unconscious/death ratio in TBI-mice was after force impulses of 0.068 N s, 0.093 N s, 0.113 N s, 0.130 N s, 0.145 N s, and 0.159 N s. Counteraction (with a reduction of unconsciousness, lower mortality) with both µg- and ng-regimens included the force impulses of 0.068–0.145 N s. A higher regimen presented effectiveness also against the maximal force impulse (0.159 N s). Furthermore, BPC 157 application immediately prior to injury was beneficial in mice subjected to force impulses of 0.093 N s-TBI. For a more severe force impulse (0.130 N s, 0.145 N s, or 0159 N s), the time-relation to improve the conscious/unconscious/death ratio was: 5 min (0.130 N s-TBI), 20 min (0.145 N s-TBI) or 30 min (0.159 N s-TBI).

traumatic brain injury ; pentadecapeptide BPC 157 ; mice

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

160 (1-3)

2010.

26-32

objavljeno

0167-0115

1873-1686

10.1016/j.regpep.2009.11.012

Povezanost rada

Temeljne medicinske znanosti

Poveznice
Indeksiranost