Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 450983

Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses


Mrakovčić, Lidija; Wildburger, Renate; Jaganjac, Morana; Cindrić, Marina; Čipak, Ana; Borović Šunjić, Suzana; Waeg, Georg; Moguš Milanković, Andrea; Žarković, Neven
Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses // Acta biochimica Polonica, 57 (2010), 2; 173-178 doi:10.18388/abp.2010_2391 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 450983 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses

Autori
Mrakovčić, Lidija ; Wildburger, Renate ; Jaganjac, Morana ; Cindrić, Marina ; Čipak, Ana ; Borović Šunjić, Suzana ; Waeg, Georg ; Moguš Milanković, Andrea ; Žarković, Neven

Izvornik
Acta biochimica Polonica (0001-527X) 57 (2010), 2; 173-178

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone regeneration ; bioactive glass ; lipid peroxidation ; 4-hydroxynonenal ; oxidative homeostasis

Sažetak
Bone regeneration is a process of vital importance since factures of long bones and large joints have a highly deleterious impact on life of individual and society. Various attempts are done to solve this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Since lipid peroxidation was defined as important parameter of systematic stress response in patients with traumatic brain injuries and bone fractures it led to recent studies of molecular mechanisms of 4-hydroxynonenal (HNE), end product of lipid peroxidation, associated with cellular growth regulation. We have found that HNE is generating in bone cells while grown in vitro on the surfaces of bioactive glasses 45S5 and 13-93. This raises interesting hypothesis of combined action of HNE and bioglass ionic dissolution products in enhanced osteogenesis probably through mitogen-activated protein kinase (MAPK) pathway. While proposed mechanism still has to be elucidated, the finding of HNE generated on bioglass offers new interpretation of osteoinducting mechanisms of bioglass and suggests promising tools in future tissue engineering based on oxidative homeostasis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Žarković, Neven, MZOS ) ( POIROT)
098-0982929-2916 - Utjecaj strukture na električna svojstva (bioaktivnih) stakala i keramike (Moguš-Milanković, Andrea, MZOS ) ( POIROT)
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Žarković, Kamelija, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Mrakovčić, Lidija; Wildburger, Renate; Jaganjac, Morana; Cindrić, Marina; Čipak, Ana; Borović Šunjić, Suzana; Waeg, Georg; Moguš Milanković, Andrea; Žarković, Neven
Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses // Acta biochimica Polonica, 57 (2010), 2; 173-178 doi:10.18388/abp.2010_2391 (međunarodna recenzija, članak, znanstveni)
Mrakovčić, L., Wildburger, R., Jaganjac, M., Cindrić, M., Čipak, A., Borović Šunjić, S., Waeg, G., Moguš Milanković, A. & Žarković, N. (2010) Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses. Acta biochimica Polonica, 57 (2), 173-178 doi:10.18388/abp.2010_2391.
@article{article, year = {2010}, pages = {173-178}, DOI = {10.18388/abp.2010\_2391}, keywords = {bone regeneration, bioactive glass, lipid peroxidation, 4-hydroxynonenal, oxidative homeostasis}, journal = {Acta biochimica Polonica}, doi = {10.18388/abp.2010\_2391}, volume = {57}, number = {2}, issn = {0001-527X}, title = {Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses}, keyword = {bone regeneration, bioactive glass, lipid peroxidation, 4-hydroxynonenal, oxidative homeostasis} }
@article{article, year = {2010}, pages = {173-178}, DOI = {10.18388/abp.2010\_2391}, keywords = {bone regeneration, bioactive glass, lipid peroxidation, 4-hydroxynonenal, oxidative homeostasis}, journal = {Acta biochimica Polonica}, doi = {10.18388/abp.2010\_2391}, volume = {57}, number = {2}, issn = {0001-527X}, title = {Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses}, keyword = {bone regeneration, bioactive glass, lipid peroxidation, 4-hydroxynonenal, oxidative homeostasis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font