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Pregled bibliografske jedinice broj: 450968

Oxidative Stress and Antioxidants: Biological Response Modifiers of Oxidative Homeostasis in Cancer


Čipak Gašparović, Ana; Lovaković, Tomislava; Žarković, Neven
Oxidative Stress and Antioxidants: Biological Response Modifiers of Oxidative Homeostasis in Cancer // Periodicum biologorum, 112 (2010), 4; 433-439 (recenziran, članak, stručni)


Naslov
Oxidative Stress and Antioxidants: Biological Response Modifiers of Oxidative Homeostasis in Cancer

Autori
Čipak Gašparović, Ana ; Lovaković, Tomislava ; Žarković, Neven

Izvornik
Periodicum biologorum (0031-5362) 112 (2010), 4; 433-439

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
Oxidative stress; antioxidants; oxidative homeostasis

Sažetak
Oxidative stress is defined as a misbalance in cell redox reactions resulting in the increase of reactive oxygen species (ROS) and/or decreased antioxidant defence. Crucial part of oxidative stress, which avoids protective effects of antioxidants, is lipid peroxidation (LPO). Since LPO comprises several chain reactions allowing the spread of ROS-caused damage to the macromolecules (proteins, nucleic acids and lipids) it is important in pathogenesis of various diseases such as cardiovascular diseases, neurodegenerative diseases, diabetes mellitus and cancer. On the other hand, research on physiology and pathology of lipid peroxidation revealed that not only ROS but also the LPO products such as 4-hydroxynonenal (HNE) are involved in physiological homeostasis of various tissues. This lead to conclusion that LPO and oxidative stress and not only pathological but also physiological processes. Accordingly, HNE was revealed as biomarker, growth regulating factor and signalling molecule. In this light, both natural as well as synthetic antioxidants could be considered as “biological response modifiers” maintaining oxidative homeostasis. Accordingly, some antioxidants might eventually become important components of advanced individual and integrative biomedicine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus