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Pregled bibliografske jedinice broj: 450612

Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma


Valković, Toni; Duletić-Načinović, Antica; Štifter, Sanja; Hasan, Milena; Hadžisejdić, Ita; Zombori, David; Grahovac, Blaženka; Jonjić, Nives
Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma // Clinical and Experimental Medicine (Testo stampato), 10 (2010), 4; 229-235 (međunarodna recenzija, članak, znanstveni)


Naslov
Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma

Autori
Valković, Toni ; Duletić-Načinović, Antica ; Štifter, Sanja ; Hasan, Milena ; Hadžisejdić, Ita ; Zombori, David ; Grahovac, Blaženka ; Jonjić, Nives

Izvornik
Clinical and Experimental Medicine (Testo stampato) (1591-8890) 10 (2010), 4; 229-235

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Non-Hodgkin lymphoma; Monocyte chemotactic protein-1

Sažetak
Non-Hodgkin lymphoma (NHL) is one of the most common malignancies whose incidence increases, and the treatment results are not satisfactory. The aim of this study was to determine the capacity of NHL to produce MCP-1, chemokine that induces chemotaxis of macrophages and lymphoid cells. The mRNA expression and protein MCP-1 expression were determined in the samples of 20 patients with NHL and 8 reactive tonsils. MCP-1 mRNA was detected in 8/8 tonsils and in 19/20 patients with NHL by real-time PCR analysis. In addition, the amount of detected MCP-1 cDNA was significantly higher in patients with limited stage, good IPI, normal level of fibrinogen and LDH. Finally, in patients with aggressive NHL, the level of MCP-1 cDNA was higher than in indolent tumours. Immunohistochemical analysis revealed that majority of stromal elements such as macrophages, endothelial and smooth muscle cells in reactive as well as in neoplastic lymphoid tissue showed strong cytoplasmic MCP-1 expression. Moderate cytoplasmic MCP-1 expression was also observed in reactive lymphocytes, while tumour cells of indolent NHL were mostly pale in comparison with aggressive lymphomas which predominantly demonstrated intense MCP-1 staining. These intriguing preliminary results emphasize the need for further investigations that must be conducted on the representative sample with concordant measurement of serum MCP-1 level.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620095-0079 - Uloga kemokina u patogenezi multiplog mijeloma (Toni Valković, )
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Nives Jonjić, )
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Antica Duletić-Načinović, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE