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Pregled bibliografske jedinice broj: 450574

Antioxidants, trace elements and metabolic syndrome in elderly subjects


Pizent, Alica; Pavlović, Mladen; Jurasović, Jasna; Dodig, Slavica; Pašalić, Daria; Mujagić, Renat
Antioxidants, trace elements and metabolic syndrome in elderly subjects // Journal of nutrition health & aging, 14 (2010), 10; 866-871 doi:10.1007/s12603-010-0139-1 (međunarodna recenzija, članak, znanstveni)


Naslov
Antioxidants, trace elements and metabolic syndrome in elderly subjects

Autori
Pizent, Alica ; Pavlović, Mladen ; Jurasović, Jasna ; Dodig, Slavica ; Pašalić, Daria ; Mujagić, Renat

Izvornik
Journal of nutrition health & aging (1279-7707) 14 (2010), 10; 866-871

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Trace elements; antioxidant enzymes; metabolic syndrome; obesity; elderly

Sažetak
Objective: To examine whether concentrations of several trace elements and activities of several antioxidant enzymes are modified in metabolic syndrome, and to evaluate their possible association with metabolic syndrome components. Additionally, concentration of CRP, as a marker of inflammation, was measured. Design: Cross-sectional study. Participants: The study group consisted of 100 subjects, aged 71-88 years. Measurements: Anthropometric measurements and biochemical analyses of fasting blood samples were performed by standardized methods. According to the International Diabetic Federation (IDF) criteria, metabolic syndrome was diagnosed in 64 subjects. Whole blood glutathione peroxidase (GPx), erythrocyte superoxide dismutase (SOD) and catalase (CAT), serum selenium (SSe), copper (SCu) and zinc (SZn), glucose, lipoprotein profile and C-reactive protein (CRP) were determined in all subjects. Results: No clear influence of metabolic syndrome on SSe, SZn and SCu concentration and SOD and CAT activity was found. However, significantly higher GPx was found in subjects with metabolic syndrome than in subjects without metabolic syndrome (p=0.029), as well as in subjects with hypertriglyceridemia than in control subjects (p=0.038). After adjusting for potentially confounding variables by multiple regression, significant positive relationship between SCu and CRP was found, indicating that elevated levels of Cu could have influence on inflammatory mechanisms. Conclusion: Our results suggest that GPx and CRP, as biomarkers of oxidative stress and chronic inflammation, respectively, have significant role in the pathogenesis of metabolic syndrome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

Napomena
Accepted on 26-02-2010 ; Online First™, 30 July 2010



POVEZANOST RADA


Projekt / tema
022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Martina Piasek, )
022-0222411-2407 - PROCJENA RIZIKA POBOLA I SMRTNOSTI U POPULACIJI HRVATSKE: - PROSPEKTIVNA STUDIJA (Mladen Pavlović, )
022-0222411-2408 - Učinci toksičnih i esencijalnih metala na reprodukcijsko zdravlje muškaraca (Alica Pizent, )
108-1080316-0298 - Molekularna osnova aterogeneze (Goran Ferenčak, )
134-0061245-0205 - Hemoreološki poremećaji u kroničnim bolestima (Nada Vrkić, )
277-2770966-0965 - Kondenzat izdaha kao izvor biomarkera plućnih bolesti u djece (Slavica Dodig, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Dječja bolnica Srebrnjak

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • CAB Abstracts
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • FSTA: Food Science and Technology Abstracts
  • CAB International
  • Current Abstracts
  • EBSCO
  • Global Health
  • Google Scholar
  • IBIDS
  • Journal Citation Reports/Science Edition
  • OCLC
  • PubMed/Medline
  • Scopus
  • Summon by Serial Solutions


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