Complex segregation analysis blood pressure in pedigree sample from Dalmatia Croatia (CROSBI ID 474789)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Škarić-Jurić, Tatjana ; Ginsburg, Emil ; Kobyliansky, Eugene ; Rudan, Pavao
engleski
Complex segregation analysis blood pressure in pedigree sample from Dalmatia Croatia
The data on systolic and diastolic blood pressure used in this study is a random (non-selected) pedigree sample of inhabitants of the Middle Dalmatia's islands of Brač, Hvar, Korčula and the Pelješac peninsula. The pedigree sample consist of 389 two and three-generation families having each from 2 to 19 observed individuals (total 1126 examinees, 526 males and 600 females, aged 17 to 87). Complex segregation analysis of pedigree data has been performed by the implementation of the program package MAN (Mendelian ANalysis of pedigree data). By usual transmission probability tests, the hypothesis has been accepted that approximately one third of the variation of sex and age adjusted values of both the systolic and diastolic blood pressure is controlled by the putative major gene (MG). The most parsimonious models of systolic and diastolic blood pressure were similar and showed that: a) inheritance of systolic and diastolic blood pressure in the Middle Dalmatia population can be attributed to the effect of a major gene responsible for 34% (systolic) and 36% (diastolic) of the blood pressure variation ; b) alleles of those major genes act in codominant fashion ; c) allele frequency for high blood pressure (A2) is 0.18 (systolic) and 0.15 (diastolic blood pressure) ; and d) the residual (non-major gene) familial correlations are negligible and can be constrained to zero.
complex segregation analysis; blood pressure; population genetics; anthropology
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Podaci o prilogu
39-x.
2000.
nije evidentirano
objavljeno
Podaci o matičnoj publikaciji
12th Congress of the European Anthropological Association Millennial Perspectives: Past, Present and Future
Mascie-Taylor, Nick
Cambridge: University of Cambridge, Department of Biological Anthropology
Podaci o skupu
12th Congress of the European Anthropological Association Millennial Perspectives:Past, Present and Future
poster
08.09.2000-11.09.2000
Cambridge, Ujedinjeno Kraljevstvo