engleski

Human papillomavirus infection among females with cytological abnormalities in Switzerland investigated by an automated linear array genotyping test

Background: Limited data are available describing human papillomavirus (HPV) genotype distribution among females with cytological abnormalities in Switzerland. Objectives: To examine HPV genotype distribution among females with cytological abnormalities in Switzerland. Study design: Cervical cell specimens obtained from 5, 300 women were routinely screened by liquid-based Pap smear. All specimens with cellular abnormalities were subsequently analysed for HPV DNA by the (automated) LINEAR ARRAY (LA) HPV genotyping test (Roche). Results: Cellular abnormalities were found in 202 (3.8%) specimens, of which 150 (74.3%) tested positive for high-risk (HR) HPV. Significantly higher prevalence of HR-HPV was observed in women with HSIL compared to ASCUS (p=0.0005) and LSIL (p=0.0011). The cumulative prevalence of HR-HPV other than HPV16 and 18 was significantly higher than HPV16 and/or 18 in ASCUS (p=0.009) and LSIL (p=0.0001) and comparable prevalence was observed in HSIL (p=0.08). The most common HR-HPV genotypes were HPV16 (15.2%), HPV31 (12.1%), HPV58 (12.1%), HPV51 (9.1%), HPV59 (9.1%) in women with ASCUS ; HPV16 (25%), HPV51 (16.9%), HPV52 (11.8%), HPV31 (9.6%), HPV56 (8.1%) in women with LSIL and HPV16 (57.6%), HPV18 (18.2%), HPV31 (15.2%), HPV52 (12.1%), HPV59 (6.1%) in women with HSIL. The highest prevalence of HR-HPV (81.9%) was detected in age-group 21-30 and showed a continuous decrease in older age-groups. Conclusions: This population-based study provides information about distribution of HPV genotypes in women with cytological abnormalities in Switzerland and is important for determining the future impact of vaccines and potential changes in the country’s epidemiological HPV profile.

HPV typing ; automated linear array HPV test ; HPV molecular epidemiology

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