engleski

The mechanism of action of rabbit-anti-human-lymphocyte serum

The aim was to test several parameters of action of xenogeneic antilymphocyte globulins of rabbit- antilymphocyte serum (RALS). Absorption with normal and leukemic lymphocytes reduced lymphocytotoxicity and the ability to inhibit rosette formation and monocite spreading. This indicate that RALS affected primarily T lymphocytes not affecting B lyphocytes. Immunophenotypisation of T subpopulations with monoclonal antibodies and flow cytometry did not discriminate the effect of RALS between helper and suppressor lymphocytes. It seems therefore that RALS is directed against all T lymphocytes.

rabbit-anti-human-lymphocyte serum/globulin ; in vitro testing

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