Napredna pretraga

Pregled bibliografske jedinice broj: 449315

HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats


Marquez-Quiñones, Adriana; Čipak, Ana; Žarković, Kamelija; Fattel-Fazenda, Samia; Villa-Treviño, Saul; Waeg, Georg; Žarković, Neven; Guéraud, Françoise
HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats // Free radical research, 44 (2010), 2; 119-127 doi:10.3109/10715760903338071 (međunarodna recenzija, članak, znanstveni)


Naslov
HNE-protein adducts formation in different pre-carcinogenic stages of hepatitis in LEC rats

Autori
Marquez-Quiñones, Adriana ; Čipak, Ana ; Žarković, Kamelija ; Fattel-Fazenda, Samia ; Villa-Treviño, Saul ; Waeg, Georg ; Žarković, Neven ; Guéraud, Françoise

Izvornik
Free radical research (1071-5762) 44 (2010), 2; 119-127

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hepatitis; LEC rats; HNE; oxidative stress

Sažetak
Lipid peroxidation is highly associated with chronic degenerative diseases such as cancer. 4-hydroxy-2-nonenal is one of the major products of lipid peroxidation. 4-hydroxy-2-nonenal can interact with biomolecules, changing their conformation and activity. This study presents 4-hydroxy-2-nonenal-protein adducts formation in the first stages of Long-Evans Cinnamon rat hepatitis, a well recognized model for oxidative stress-associated hepatocarcinogenesis. 4-hydroxy-2-nonenal-protein adducts appeared in hepatocyte cytoplasm before the beginning of hepatitis and their presence was very strong during hepatitis, while a transient perinuclear expression of 4-hydroxy-2-nonenal-protein adducts was shown mainly at early hepatitis stages. 4-hydroxy-2-nonenal-protein adducts formation correlated to the expression of the tumour marker glutathione S-transferase P-form. These results show that lipid peroxidation modification of proteins might be implicated in the first stages of hepatocyte cancer initiation in Long-Evans Cinnamon rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati