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Pregled bibliografske jedinice broj: 449303

Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury


Gjurašin, Miroslav; Miklić, Pavle; Župančić, Božidar; Perović, Darko; Žarković, Kamelija; Brčić, Luka; Kolenc, Danijela; Radić, Božo; Seiwerth, Sven; Sikirić, Predrag
Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury // Regulatory peptides, 160 (2010), 1/3; 33-41 doi:10.1016/j.regpep.2009.11.005 (međunarodna recenzija, članak, znanstveni)


Naslov
Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Autori
Gjurašin, Miroslav ; Miklić, Pavle ; Župančić, Božidar ; Perović, Darko ; Žarković, Kamelija ; Brčić, Luka ; Kolenc, Danijela ; Radić, Božo ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Regulatory peptides (0167-0115) 160 (2010), 1/3; 33-41

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Pentadecapeptide BPC 157 ; rat ; transected nerve

Sažetak
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 µg, 10 ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube. Improvement was shown clinically (autotomy), microscopically/morphometrically and functionally (EMG, one or two months post-injury, walking recovery (sciatic functional index (SFI)) at weekly intervals). BPC 157-rats exhibited faster axonal regeneration: histomorphometrically (improved presentation of neural fascicles, homogeneous regeneration pattern, increased density and size of regenerative fibers, existence of epineural and perineural regeneration, uniform target orientation of regenerative fibers, and higher proportion of neural vs. connective tissue, all fascicles in each nerve showed increased diameter of myelinated fibers, thickness of myelin sheet, number of myelinated fibers per area and myelinated fibers as a percentage of the nerve transected area and the increased blood vessels presentation), electrophysiologically (increased motor action potentials), functionally (improved SFI), the autotomy absent. Thus, BPC 157 markedly improved rat sciatic nerve healing.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )
108-1080231-0324 - Promjene telencefaličke stijenke u bolesnika sa hidrocefalusom (Pavle Miklić, )
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Sven Seiwerth, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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