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Lipid peroxidation product acrolein as a predictive biomarker of prostate carcinoma relapse after radical surgery


Ćustović, Zajim; Žarković, Kamelija; Cindrić, Marina; Čipak, Ana; Jurković, Ilija; Sonicki, Zdenko; Uchida, Koji; Žarković, Neven
Lipid peroxidation product acrolein as a predictive biomarker of prostate carcinoma relapse after radical surgery // Free radical research, 44 (2010), 497-504 doi:10.3109/10715761003636831 (međunarodna recenzija, članak, znanstveni)


Naslov
Lipid peroxidation product acrolein as a predictive biomarker of prostate carcinoma relapse after radical surgery

Autori
Ćustović, Zajim ; Žarković, Kamelija ; Cindrić, Marina ; Čipak, Ana ; Jurković, Ilija ; Sonicki, Zdenko ; Uchida, Koji ; Žarković, Neven

Izvornik
Free radical research (1071-5762) 44 (2010); 497-504

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Prostate cancer; acrolein; lipid peroxidation; biomarker

Sažetak
Cancer recurrence after radical surgery might happen even in the case of patients with localized prostate carcinoma treated by radical prostatectomy. Therefore, identifying predictive markers of tumour recurrence is very important, so this study evaluated the presence of lipid peroxidation product acrolein in primary prostate carcinomas, assuming that acrolein could be involved in prostate carcinogenesis as was recently shown for colon cancer. Samples obtained by radical prostatectomy of 70 patients were analysed, out of which 27 patients suffered afterwards from tumour recurrence, while 43 patients were disease free. Immunohistochemistry using genuine monoclonal antibodies against acrolein-protein adducts revealed the association of acrolein with progression of carcinoma. The logistic regression combining clinical parameters together with the biochemical markers of disease and acrolein immunohistochemistry has shown that the relapse might be predicted with 90% accuracy if tumour-positive surgical margins, stage of disease and the intensity of acrolein presence in tumour stroma were taken together.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )
108-0982560-0257 - Prediktivni modeli u zdravstvu (Zdenko Sonicki, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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