engleski

Population structure analysis - population cohorts and their longevity

Isolates provide unique opportunities to explore genetic variation effects on population structure, but they also represent a good setting for genetic studies of complex diseases. It is of great importance to analyze the influence of sociocultural, economical, demographic and ethnohistorical data on the patterns of longevity demonstrated by some specific isolate subpopulations as well as their cohorts. Such studies provide insight into some basic models and patterns of population structure, which is later reflected in its epidemiological, genetic and basic medical characteristics. In this particular study, an attempt was made to correlate the population genetic pecularities reflected in traits such as erythrocyte polymorphysms, studied more than 20 years earlier, with current medical status of investigated populations, namely the cancer prevalence. The valuable possibility of conducting this prospective (longitudinal, cohort) study is a solid basis for the aim of delineating whether some erythrocyte antigens imply greater relative risk of developing cancer.

population structure; population cohorts; anthropology; population genetics

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