Tandem [4+2]/[3+2] cycloadditions of 1, 3, 4-oxadiazoles with alkenes (CROSBI ID 159845)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Margetić, Davor ; Trošelj, Pavle ; Johnston, Martin R.
engleski
Tandem [4+2]/[3+2] cycloadditions of 1, 3, 4-oxadiazoles with alkenes
A review on the tandem [4+2]/[3+2] cycloaddition reactions of 1, 3, 4-oxadiazoles with alkenes is presented. This reaction presents a powerful synthetic tool in the construction of complex polycyclic molecules in a one-pot reaction. Special attention is payed to synthesis of [n]polynorbornane and oxanorbornyl systems. In continuation, a review on the 1, 3, 4-oxadiazole reactions used in stereoselective total synthesis of alkaloids is given. Both intermolecular and intramolecular tandem [4+2]/[3+2] reactions are discussed. Stereospecificities and mechanistic rationale of various reactions are supported by quantum-chemical calculations (RHF/6-31G*).
cycloadditions ; oxadiazoles ; synthesis
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Podaci o izdanju
8 (1)
2011.
49-65
objavljeno
1570-193X
1875-6298
10.2174/157019311793979981