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DIFFERENTIAL DIAGNOSIS AND DIAGNOSTIC ALGORITHM OF DEMYELINATING DISEASES

Demyelinating diseases of the central nervous system include a wide spectrum of different disorders that may resemble multiple sclerosis (MS). The diagnosis of MS is based on typical clinical and parac1inical criteria. The simplified McDonald's criteria, which combine clinical picture, NMR findings, CSF analysis and visual evoked potentials, are appropriate for daily neurologic routine. Ifsome of these criteria are atypical, diagnostic algorithm should be extended to some other procedures to exclude other diseases that can mimic MS not only in symptoms, signs or course of the disease but also in laboratory findings. In such a case, an alternative, better explanation for the clinical manifestations should be considered and performing specific tests is helpful to exclude alternative diagnoses.

Neurology - standards; Diagnosis; differential; Nervous system diseases - diagnosis; Algorithms; Demyelinating diseases- diagnosis

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