engleski

Thrombolysis for acute ischemic stroke - our experiences as part of sits-most

Thrombolysis with intravenous recombinant tissue plasminogen activator (rtPA) is the first evidence based treatment for acute ischemic stroke, which aims to reduce the cerebrovascularlesion. At University Department ofNeurology, Sestre milosrdnice University Hospital, Zagreb, thrombolytic therapy with intravenous rtPA (alteplase) (Actrlyse") for acute ischemic stroke was introduced in 2004. We present our results referring to demographic, time logistics and clinical outcome data as part of SITS-MOST (Safe Implementation ofThrombolysis in Stroke - MOnitoring STudy) and compare them with the results from other centers in Croatia and all other participating centers. Up to now, 56 patients (61% ofmale and 39% offemale, average age 67 years) have been treated at our department with intravenous rt-PA (0.9 mg/kg body weight, maximum 90 mg). with 10% ofthe dose given as a bolus followed by 60- minute infusion. Our experiences with thrombolytic therapy with intravenous rt-PA (alteplase) (Aculyse") for acute ischemic stroke confirm the safety and the efficacy of this therapy.

Brain ischemia - drug therapy ; Stroke - drug therapy ; 7hrombolytic therapy ; Fibrinolytic agents - therapeutic use

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