Napredna pretraga

Pregled bibliografske jedinice broj: 447763

Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids


Sornosa-Ten, Alejandra; Albelda, M. Teresa; Frías, Juan C.; García-España, Enrique; Llinares, José M.; Budimir, Ana; Piantanida, Ivo
Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids // Organic & biomolecular chemistry, 8 (2010), 11; 2567-2574 doi:10.1039/c000124d (međunarodna recenzija, članak, znanstveni)


Naslov
Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids

Autori
Sornosa-Ten, Alejandra ; Albelda, M. Teresa ; Frías, Juan C. ; García-España, Enrique ; Llinares, José M. ; Budimir, Ana ; Piantanida, Ivo

Izvornik
Organic & biomolecular chemistry (1477-0520) 8 (2010), 11; 2567-2574

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tripodal polyamines; DNA and RNA interactions; RNA selectivity; nucleotides

Sažetak
Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati