Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids (CROSBI ID 159609)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Sornosa-Ten, Alejandra ; Albelda, M. Teresa ; Frías, Juan C. ; García-España, Enrique ; Llinares, José M. ; Budimir, Ana ; Piantanida, Ivo
engleski
Acid-base properties of functionalised tripodal polyamines and their interaction with nucleotides and nucleic acids
Novel, highly positively charged tripodal polyamines with appended heterocyclic moieties revealed an intriguing panel of protonation species within the biologically relevant range. Studied compounds bind nucleotide monophosphates by mostly electrostatic interactions but only the imidazole analogue showed selectivity toward UMP in respect to other nucleotides. Strong binding of all the studied compounds to both ds-DNA and ds-RNA is to some extent selective toward the latter, showing rather rare RNA over DNA preference.
tripodal polyamines; DNA and RNA interactions; RNA selectivity; nucleotides
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Podaci o izdanju
Povezanost rada
Kemija, Temeljne medicinske znanosti