engleski

Recognition of single stranded and double stranded DNA / RNA sequences in aqueous medium by small bis-aromatic derivatives

The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure – DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator – nucleobase conjugates.

DNA and RNA binding ; bis-intercalation ; macrocyclic bis-intercalation ; intercalator – nucleobase conjugate

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