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Recognition of single stranded and double stranded DNA / RNA sequences in aqueous medium by small bis-aromatic derivatives


Tumir, Lidija-Marija; Piantanida, Ivo
Recognition of single stranded and double stranded DNA / RNA sequences in aqueous medium by small bis-aromatic derivatives // Mini-reviews in medicinal chemistry, 10 (2010), 4; 299-308 (međunarodna recenzija, članak, znanstveni)


Naslov
Recognition of single stranded and double stranded DNA / RNA sequences in aqueous medium by small bis-aromatic derivatives

Autori
Tumir, Lidija-Marija ; Piantanida, Ivo

Izvornik
Mini-reviews in medicinal chemistry (1389-5575) 10 (2010), 4; 299-308

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA and RNA binding; bis-intercalation; macrocyclic bis-intercalation; intercalator – nucleobase conjugate

Sažetak
The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure – DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator – nucleobase conjugates.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE