engleski

Interleukin-17 in experimental Klebsiella sepsis

Background and pupose: Interleukin-17 (IL-17) is a cytokine that was described to be important in pathogenesis of several inflammatory conditions. Literature data suggest that modulation of IL-17 production or its biological effects may be beneficial in order to control the level of inflammation. However, data regarding its possible role in the pathogenesis of systemic infections are sparse. Materials and methods: Therefore, we decided to examine the kinetics of systemic IL- 17 production in our model of experimental murine Klebsiella sepsis. We also examined IL- 17 production in mice treated with anti- lipopolysaccharide (anti-LPS) antibody prior to infection in order to see whether this pre- treatment, that was previously shown to significantly enhance the survival, is associated with changes in IL-17 production pattern. Results: Our results show that experimental Klebsiella sepsis is associated with an increased systemic IL-17 production. The increase in production is much greater in saline pre-treated group compared with anti-LPS pre-treated animals. Conclusions: We concluded that high levels of IL-17 in the blood may contribute the mortality in mice with systemic Klebsiella infection. We also concluded that diminished IL-17 production in anti-LPS pre- treated animals is, at least partially, responsible for greater survival in this group.

Interleukin-17; Klebsiella pneumoniae; sepsis

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