engleski

PROSPECTIVE SURVEILLANCE OF CROATIAN PREGNANT WOMEN ON LAMOTRIGINE MONOTHERAPY - ASPECTS OF PRE-PREGNANCY COUNSELING AND DRUG MONITORING

We prospectively surveyed 23 pregnant women with epilepsy on lamotrigine monotherapy and reported outcome oftheir pregnancies, including one fetal intrauterine death, one spontaneous abortion and two preterm deliveries. There were no congenital malformations in their offspring. Women with pregnancy planning and folic acid intake delivered babies with higher values ofbirth weight and birth length. There was large inter-patient variation during drug monitoring and in the need of dose adjustment. Individual approach to every woman and monotherapy with minimal effective lamotrigine dose with frequent drug monitoring enhances the possibility for successful pregnancy. The management ofwomen with epilepsy should begin with pre-pregnancy counseling. Planned pregnancy enables periconceptional folic acid supplementation. Despite the small number of cases, these data indicate that la motrigine treatment during pregnancy might be relatively safe. Larger prospective studies are needed to obtain adequate power for statistical analysis including long-term cohort studies.

Pregnancy - complications; Pregnancy - drug therapy; Epilepsy - drug therapy; Epilepsy metabolism; Anticonvulsants - blood

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