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Pregled bibliografske jedinice broj: 447454

Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes


Bućan, Kajo; Ivanišević, Milan; Zemunik, Tatijana; Boraska, Vesna; Škrabić, Veselin; Vatavuk, Zoran; Galetović, Davor; Znaor, Ljubo
Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes // Collegium antropologicum, 33 (2009), S2; 99-105 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 447454 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes

Autori
Bućan, Kajo ; Ivanišević, Milan ; Zemunik, Tatijana ; Boraska, Vesna ; Škrabić, Veselin ; Vatavuk, Zoran ; Galetović, Davor ; Znaor, Ljubo

Izvornik
Collegium antropologicum (0350-6134) 33 (2009), S2; 99-105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diabetes mellitus Type 1 ; genes ; diabetic retinopathy ; diabetic nephropathy ; microalbuminuria ; Croatia

Sažetak
Retinopathy and nephropathy are common late type 1 diabetes mellitus (T1D) complications. In this study we investigated whether individual differences in 4 candidate genes significantly contribute to development and progression of late complications in T1D patients. We examined 121 patients for the presence of diabetic retinopathy and nephropathy. We genotyped variants in vitamin D receptor (VDR) and tumor necrosis factor (TNF) genes in 47 patients and in NeuroD1 and interleukin-1 receptor 1 (IL1R1) genes in 35 patients. Diabetic retinopathy had 66 (55%) patients after a median of 13.0 years after diagnosis. Diabetic nephropathy had 14 (11.66%) patients, all of whom had already developed retinopathy. A significant correlation between the degree of diabetic retinopathy and mean microalbuminuria (MA) value has been found (chi2 = 54.18, p < 0.001). After correcting for duration of disease, only the VDR gene BsmI genotypes showed significant association with cumulative prevalence of diabetic retinopathy, while no investigated genetic polymorphysms could reliably predict diabetic nephropathy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekti:
MZOS-216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Zemunik, Tatijana, MZOS ) ( POIROT)

Ustanove:
KBC "Sestre Milosrdnice",
KBC Split,
Medicinski fakultet, Split


Citiraj ovu publikaciju:

Bućan, Kajo; Ivanišević, Milan; Zemunik, Tatijana; Boraska, Vesna; Škrabić, Veselin; Vatavuk, Zoran; Galetović, Davor; Znaor, Ljubo
Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes // Collegium antropologicum, 33 (2009), S2; 99-105 (međunarodna recenzija, članak, znanstveni)
Bućan, K., Ivanišević, M., Zemunik, T., Boraska, V., Škrabić, V., Vatavuk, Z., Galetović, D. & Znaor, L. (2009) Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes. Collegium antropologicum, 33 (S2), 99-105.
@article{article, author = {Bu\'{c}an, Kajo and Ivani\v{s}evi\'{c}, Milan and Zemunik, Tatijana and Boraska, Vesna and \v{S}krabi\'{c}, Veselin and Vatavuk, Zoran and Galetovi\'{c}, Davor and Znaor, Ljubo}, year = {2009}, pages = {99-105}, keywords = {diabetes mellitus Type 1, genes, diabetic retinopathy, diabetic nephropathy, microalbuminuria, Croatia}, journal = {Collegium antropologicum}, volume = {33}, number = {S2}, issn = {0350-6134}, title = {Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes}, keyword = {diabetes mellitus Type 1, genes, diabetic retinopathy, diabetic nephropathy, microalbuminuria, Croatia} }
@article{article, author = {Bu\'{c}an, Kajo and Ivani\v{s}evi\'{c}, Milan and Zemunik, Tatijana and Boraska, Vesna and \v{S}krabi\'{c}, Veselin and Vatavuk, Zoran and Galetovi\'{c}, Davor and Znaor, Ljubo}, year = {2009}, pages = {99-105}, keywords = {diabetes mellitus Type 1, genes, diabetic retinopathy, diabetic nephropathy, microalbuminuria, Croatia}, journal = {Collegium antropologicum}, volume = {33}, number = {S2}, issn = {0350-6134}, title = {Retinopathy and nephropathy in type 1 diabetic patients - association with polymorphysms of vitamin D-receptor, TNF, Neuro-D and IL-1 receptor 1 genes}, keyword = {diabetes mellitus Type 1, genes, diabetic retinopathy, diabetic nephropathy, microalbuminuria, Croatia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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