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Pregled bibliografske jedinice broj: 446707

How activity of inflammatory bowel disease influences bone loss


Crnčević Orlić, Željka; Turk, Tamara; Mijandrušić Sinčić, Brankica; Štimac, Davor; Cvijanović, Olga; Marić, Ivana; Ilić Tomaš, Maja; Jurišić-Eržen, Dubravka; Licul, Vanja; Bobinac, Dragica
How activity of inflammatory bowel disease influences bone loss // Journal of clinical densitometry, 13 (2010), 1; 36-42 doi:10.1016/j.jocd.2009.12.002 (međunarodna recenzija, članak, znanstveni)


Naslov
How activity of inflammatory bowel disease influences bone loss

Autori
Crnčević Orlić, Željka ; Turk, Tamara ; Mijandrušić Sinčić, Brankica ; Štimac, Davor ; Cvijanović, Olga ; Marić, Ivana ; Ilić Tomaš, Maja ; Jurišić-Eržen, Dubravka ; Licul, Vanja ; Bobinac, Dragica

Izvornik
Journal of clinical densitometry (1094-6950) 13 (2010), 1; 36-42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Corticosteroids; duration and activity of disease; IBD; osteoporosis

Sažetak
Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD (p=0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis (p=0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
062-0000000-0219 - Genetsko testiranje bolesnika s kroničnim bolestima tankoga crijeva (Brankica Mijandrušić-Sinčić, )
062-0620226-0207 - Promjene koštanog metabolizma u bolestima bubrega i jetre (Dragica Bobinac, )
062-0620226-0208 - Kost kao ciljni organ u šećernoj bolesti i upalnim bolestima crijeva (Željka Crnčević Orlić, )
062-0620226-0209 - Koštani morfogenetski protein-7 i kost u modelu upalne bolesti crijeva (Ivana Marić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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