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Hydroxyurea and hydroxamic acid derivatives as antitumor drugs


Šaban, Nina; Bujak, Maro
Hydroxyurea and hydroxamic acid derivatives as antitumor drugs // Cancer chematotherapy and pharmacology, 64 (2009), 2; 213-221 doi:10.1007/s00280-009-0991-z (recenziran, pregledni rad, stručni)


Naslov
Hydroxyurea and hydroxamic acid derivatives as antitumor drugs

Autori
Šaban, Nina ; Bujak, Maro

Izvornik
Cancer chematotherapy and pharmacology (0344-5704) 64 (2009), 2; 213-221

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
Hydroxyurea. hydroxamic acid derivatives; cancer

Sažetak
Hydroxyurea has been used for decades and it is still valuable for the treatment of some types of cancer. It inhibits ribonucleotide reductase (RNR) enzyme known to be crucial in the conversion of ribonucleotides into deoxyribonucleotides. However, nowadays the main focus has shifted to structurally similar hydroxamic acid derivatives that target specific enzymes involved in cancer progression such as histone deacetylasesm, matrix metalloproteinases and also RNR.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )
125-0982464-2922 - RAZVOJ NOVIH PROLIJEKOVA I LIJEKOVA PROTIV VIRUSA I RAKA (Mladen Mintas, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Autor s matičnim brojem:
Nina Šaban, (268320)
Maro Bujak, (305001)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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