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Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients


Polašek, Ozren; Gunjača, Grgo; Kolčić, Ivana; Zgaga, Lina; Džijan, Snježana; Smolić, Robert; Smolić, Martina; Milas-Ahić, Jasminka; Šerić, Vatroslav; Galić, Josip et al.
Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients // Croatian medical journal, 51 (2010), 1; 48-53 doi:10.3325/cmj.2010.51.48 (međunarodna recenzija, članak, znanstveni)


Naslov
Association of Nephrolithiasis and Gene for Glucose Transporter Type 9 (SLC2A9) : Study of 145 Patients

Autori
Polašek, Ozren ; Gunjača, Grgo ; Kolčić, Ivana ; Zgaga, Lina ; Džijan, Snježana ; Smolić, Robert ; Smolić, Martina ; Milas-Ahić, Jasminka ; Šerić, Vatroslav ; Galić, Josip ; Tucak-Zorić, Sandra ; Tucak, Antun ; Rudan, Igor ; Lauc, Gordan

Izvornik
Croatian medical journal (0353-9504) 51 (2010), 1; 48-53

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nephrolithiasis; uric acid; SLC2A9

Sažetak
To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9. A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research at the Medical School Osijek, Osijek, Croatia ; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267). There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175 ; P=0.006 for rs6449213 ; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval, 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance. Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


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Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
GENOS d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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