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Uric Acid : the past decade

Rudan, Diana; Polašek, Ozren; Kolčić, Ivana; Rudan, Igor
Uric Acid : the past decade // Croatian medical journal, 51 (2010), 1; 1-6 doi:10.3325/cmj.2010.51.1 (međunarodna recenzija, pregledni rad, znanstveni)

Uric Acid : the past decade

Rudan, Diana ; Polašek, Ozren ; Kolčić, Ivana ; Rudan, Igor

Croatian medical journal (0353-9504) 51 (2010), 1; 1-6

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Uric acid; urate; gout

In the greater tree of life, the “rise” of uric acid in circulation of living organisms is a relatively recent event. In the majority of species that generate uric acid as the end-product of purine metabolism, urate is transformed into a more soluble allantoin by urate oxidase (“uricase”). However, it is presently believed that some 10-20 million years ago two independent mutations in the uricase gene occurred, and they were kept in a very small subset of species (including the ancestors of apes and humans) – most likely by positive selection. Many elements of this story remain a mystery even to this date. Why did some primates lose uricase activity some 15 million years ago? What was the selective advantage of having 10-fold higher serum urate levels compared to other mammals? Was it related to the development of cognitive abilities? Did it serve as a protection against infectious agents of those times? Did it buffer the effects of oxidative stress and contribute to present-day longevity? Why do human males have much higher serum levels than females? Is uric acid a friend or a foe – is it a protective factor or a risk factor, and against (or for) what? What levels should be considered too high? Or too low? What causes the variation in its levels within and between humans? All these fundamental questions remain unanswered to this day.

Izvorni jezik

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita


Projekt / tema
198-1080315-0292 - Nasljedne i okolišne odrednice duboke starosti - hrvatski stogodišnjaci (Diana Rudan, )
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Medicinski fakultet, Split

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus