Laser Capture Microdissection and PCR for analysis of HPV Infection (CROSBI ID 558590)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Grahovac, Blaženka ; Hadžisejdić, Ita ; Krašević, Maja
engleski
Laser Capture Microdissection and PCR for analysis of HPV Infection
Human papillomavirus (HPV) infection is considered as one of main factors involved in the pathogenesis of squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Our previous study revealed a high prevalence of high-risk (hr) HPV-DNA in examined cervical lesioons (>90%). HPV-16 predominated in SCC (65%) and HPV-18 in ADC (67.6%). The prevalence of particular hr-HPV types in adenosquamous carcinoma (ADSQ) is controversal as well as the presence of different HPV types within this tumor. Tha aim of this study was to detect hr-HPV DNA and to determine the HPV type in microdissected tissue of 4 cases of cervical adenosquamous carcinoma using lase capture microdissection (P.A.L.M.) followed by DNA extraction and qualitative PCR. Our results confirm the associtaion of certain hr-HPV types to different histological entity of ADSQ and importance of microdissection in molecular diagnostics.
HPV; HPV infection; laser capture microdisection; cervical cancer
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Podaci o prilogu
44-44.
2007.
objavljeno
Podaci o matičnoj publikaciji
International Workshop on Human Papillomavirus and Consensus Recommendations for Cervical Cancer Prevention and Colposcopy Training
Grce, Magdalena
Zagreb: Institut Ruđer Bošković
978-953-6690-65-7
Podaci o skupu
International workshop on Human Papillomaviruses and consensus recommendations for cervical cancer prevention & colposcopy training
predavanje
18.04.2007-21.04.2007
Dubrovnik, Hrvatska