engleski

A comparative study of granzyme B expression in keratoacanthoma and squamous cell carcinoma

Keratoacanthoma (KA) is a cutaneous neoplasm characterized by initial intensive growth and usually spontaneous regression [1]. Squamous cell carcinoma (SCC) is a malignant proliferation of the epithelial cells of the skin and mucous membranes characterized by locally destructive growth and tendency to metastases [1]. The most important feature that separates these closely related entities is a tendency of KA to regress but causes and detailed mechanism of this regression are still not completely elucidated. This study revealed significantly increased number of T cells expressing granzyme B in rKA comparing to SCCs, suggesting a possible role of granzyme B in KA regression. A weak cytoplasmic staining in some malignant keratinocytes, especially in KAs, suggests that these cells may have been exposed and damaged by cytotoxic proteins released from the neighboring T cells. Data from our study confirm previous findings that T lymphocytes infiltrating SCCs are functionally defective.

granzyme B; keratoacanthoma; squamous cell carcinoma

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