engleski

Effects of various cholinomimetic agents on passive avoidance behaviour in the nucleus basalis lesioned rats

A hypocholinergic animal model of Alzheimer's disease was developed by producing bilateral electrolytic lesions of the nucleus basalis (NB) in rats. Brain lesioned rats demonstrated significant impairment of passive avoidance compared to control animals both drug naive, without lesions and sham-operated animals. The ACh precursor lecithin and the muscarinic agonist arecoline significantly improved passive avoidance in the NB lesioned rats. The AChE inhibitors physostigmine, galanthamine, and tetrahyidroaminoacridine were ineffective in reversing the memory deficits in the NB lesioned rats.

nucleus basalis lesion ; cholinomimetics ; passive avoidance

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