engleski

Virus Interactions with NK Cell Receptors

Natural killer cells are among the first cells of the immune response to recognize and react to threats. They do so by surveying other cells for aberrant behavior such is altered expression of MHC I and molecules produced or induced by pathogens. As such, they’re very important in host resistance to viral infection. Various unrelated viruses have evolved numerous evasion techniques in order to avoid detection by NK cells. The many immunoevasive techniques may be roughly divided into two main groups: camouflage of infected cells aimed at inhibitory receptors and obstruction of activating receptors. By differential downmodulation of MHC I molecules and production of MHC I homologues, viruses prevent CTL recognition and camouflage their presence from NK cells. Additionally, viruses have dedicated an even greater attention towards prevention of engagement of activating receptors by interfering with the receptors per se, downmodulation of their ligands and co-activating molecules, providing soluble competitors, modification and interference with translation of ligands.

NK cell receptors, virus

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